Rt-PA Infusion Versus Catheter Exchange for Dialysis Catheter Malfunction Due to Fibrin Sheath

Stopped early · Not applicable

Conditions studied: Dialysis Catheter Fibrin Sheath, Clotted Dialysis Catheter, Catheter Malfunction

In brief

Treating central venous dialysis catheter malfunction due to fibrin sheath formation with rt-PA(TPA)infusion will give equal patency rates in a more cost effective manner when compared to catheter exchange. Subjects are randomized to TPA infusion or catheter exchange and then followed for catheter function at the post treatment dialysis session, 30-day dialysis session and 60-day dialysis session. Costs and treatment results will be compared.

Key facts

Study ID

NCT00194181

Run by

University of Pennsylvania

People needed

40

Starts

2003-03-01

Expected to finish

2005-03-01

Last updated by the study team

2006-07-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with tunneled hemodialysis catheters who have clinical evidence of catheter tip clot and fibrin sheath formation

You may not qualify if…

• Malpositioned or kinked catheter requiring catheter change
• Complete thrombosis of the catheterized vein
• Evidence of catheter related infection
• GI bleed within 6 weeks
• Cerebral Infarct within 6 months
• Major surgery within 4 weeks
• Platelet count below 25000
• INR above 2.0
• Sepsis
• Pregnancy
• Inability to give consent

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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