Docetaxel Plus Imatinib Mesylate in Metastatic Breast Cancer

Completed · Phase 2

Conditions studied: Breast Cancer

In brief

This trial evaluates the novel combination of docetaxel with imatinib as first or second line therapy in advanced breast cancer with the aim of achieving higher effectiveness and potentially reducing side effects.

Key facts

Study ID

NCT00193180

Run by

SCRI Development Innovations, LLC

People needed

37

Starts

2005-05-01

Expected to finish

2009-01-01

Last updated by the study team

2016-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• To be included in this study, you must meet the following criteria:
• Metastatic breast cancer confirmed by biopsy
• No more than one prior chemotherapy regimen for metastatic breast cancer
• Able to perform activities of daily living with minimal assistance
• Adequate bone marrow, liver and kidney function
• Age 18 years or older
• Give written informed consent

You may not qualify if…

• You cannot participate in this study if any of the following apply to you:
• Moderate to severe peripheral neuropathy
• Uncontrolled blood pressure or uncontrolled heart beat irregularities
• Diabetes Mellitus with fasting blood sugar greater than 200 mg %
• Significant heart disease within the prior 6 months
• Severe or uncontrolled medical disease
• Active uncontrolled infection
• Known chronic liver disease
• Known diagnosis of HIV infection
• Pregnant or breast feeding females
• Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.

Where it is running

• Northeast Georgia Medical Center — Gainesville, Georgia, United States
• Consultants in Blood Disorders and Cancer — Louisville, Kentucky, United States
• Baton Rouge General Medical Center — Baton Rouge, Louisiana, United States
• Methodist Cancer Center — Omaha, Nebraska, United States
• Oncology Hematology Care — Cincinnati, Ohio, United States
• Tennessee Oncology — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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