Impact of Genetics on Metformin Pharmacokinetics

Completed · Not applicable

Conditions studied: Other Conditions That May Be A Focus of Clinical Attention

In brief

Specific Aims: To compare metformin pharmacokinetics in monozygotic and dizygotic twin pairs. Comparing renal clearance of metformin in monozygotic and dizygotic twins will allow us to better understand the influence of heredity on variation in renal elimination. Furthermore, genotyping renal transporter genes in monozygotic and dizygotic twin pairs with significant differences in renal clearance of metformin may give us insight into the genes responsible for this variability.

Key facts

Study ID

NCT00187798

Run by

University of California, San Francisco

People needed

24

Starts

2001-08-01

Expected to finish

2007-07-01

Last updated by the study team

2012-09-25

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Part of either a monozygotic or dizygotic twin pair.
• Healthy (by medical history and laboratory values).
• Between 18 and 40 years old.

You may not qualify if…

• Taking regular medication other than vitamins.
• Individuals with anemia (hemoglobin < 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL Pregnant at time of study.
• Diagnosis of hypoglycemia, phlebitis and/or stroke will be excluded.

Where it is running

• University of California San Francsico — San Francisco, California, United States

Full record on ClinicalTrials.gov

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