Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects

Completed · Phase 4

Conditions studied: Other Conditions That May Be A Focus of Clinical Attention

In brief

Specific Objectives: * To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who carry the common allele. * To determine if individuals who carry the decreased or non-functional variants exhibit differences in the response to metformin in comparison to individuals who carry the common allele.

Key facts

Study ID

NCT00187681

Run by

University of California, San Francisco

People needed

20

Starts

2003-07-01

Expected to finish

2008-03-01

Last updated by the study team

2013-01-08

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Previous participation in the Study Of Pharmacogenetics In Ethnically Diverse Populations (SOPHIE) study.
• Between the ages of 18 and 40.
• Possess a specific OCT1 genotype.

You may not qualify if…

• Taking any medications other than vitamins
• Individuals with anemia (hemoglobin < 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL)
• Pregnant at time of study.

Where it is running

• San Francisco General Hospital — San Francsico, California, United States

Full record on ClinicalTrials.gov

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