Effect of an Inhaled Corticosteroid on Airway Gene Expression in Asthma
Completed · Not applicable
Conditions studied: Asthma
In brief
The purpose of this study is to determine whether an inhaled corticosteroid (fluticasone) alters the expression of any gene expressed in the lining of the airways of asthmatics. The study uses high density gene chips which allow the study investigators to measures all gene in the human genome. We hypothesize that this approach will identify novel genes that are affected by steroids in asthmatics.
Key facts
- Study ID
- NCT00187499
- Run by
- University of California, San Francisco
- Starts
- 2002-10-01
- Expected to finish
- 2005-02-01
- Last updated by the study team
- 2008-04-03
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male and female patients with a history of asthma between the ages of 18 and 70 years.
- PC20FEV1 Methacholine ≤ 8.0 mg/mL.
- At least one of the following symptoms, beta agonist use, or FEV1 criteria:
- Asthma symptoms on at least two days per week or Beta agonist use on at least two days per week or FEV1 < 85% predicted
- Subjects must be non-smokers (patients who have never smoked or patients who have not smoked for 1 year and have a total pack-year smoking history < 15 packs).
You may not qualify if…
- History of oral or inhaled steroid use in the past 4 weeks.
- FEV1 < 60% predicted.
- Lung disease other than asthma.
- Patients with a history of a respiratory tract infection in the 4 weeks preceding the study.
- Patients who have experienced a significant exacerbation in their asthma in the 6 weeks prior to the study.
- Patients receiving hyposensitization therapy with the exception of those who are on a stable dose for the last three months.
- Patients with cardiovascular disease (active) peptic ulcer disease or diabetes mellitus.
- Females who are lactating or who are pregnant.
Where it is running
- Airway Clinical Research Center, Room 1303 Moffitt, UCSF Medical Center — San Francisco, California, United States
Full record on ClinicalTrials.gov
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