Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

Stopped early · Phase 3

Conditions studied: Acute Lymphoblastic Leukemia

In brief

The main purpose of this study is to find out if radiation to the central nervous system (CNS) can be safely omitted with early intensification of chemotherapy and chemotherapy given directly to the CNS. Another purpose is to find out if survival of children with ALL can be improved with risk-directed therapy given on this protocol.

Key facts

Study ID

NCT00187005

Run by

St. Jude Children's Research Hospital

People needed

53

Starts

1998-07-01

Expected to finish

2002-07-01

Last updated by the study team

2011-03-30

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of non-B-cell leukemia by immunophenotyping (e.g. T-cell, B-cell precursor, or acute undifferentiated leukemia)
• Ages less than or equal to 18 years of age
• One week or less of prior therapy, limited to glucocorticoids, vinca alkaloids, emergency radiation therapy to the mediastinum and one dose of intrathecal chemotherapy Exclusion Criteria
• Participants greater than 18 years of age

Where it is running

• St.Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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