Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients

Completed

Conditions studied: Leukemia, Lymphoma, Tumor Lysis Syndrome, Hyperuricemia

In brief

This is a multi-center trial for rasburicase in children at high risk of tumor lysis syndrome who have a history of asthma/atopy. The main purpose of this study is to establish the safety of this drug in patients with a history of asthma or severe allergies.

Key facts

Study ID

NCT00186940

Run by

St. Jude Children's Research Hospital

People needed

16

Starts

2005-03-01

Expected to finish

2010-02-01

Last updated by the study team

2017-04-25

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of hematologic malignancy.
• Existing hyperuricemia or high risk of developing hyperuricemia of malignancy.
• The treating clinician plans to treat the patient with rasburicase. A patient is only eligible for RASALL if the clinician has already decided to use rasburicase. Rasburicase should not be given in order to make a patient eligible for this non-therapeutic observational study.
• No prior exposure to rasburicase or other urate oxidase.
• A history of asthma or significant allergy.

You may not qualify if…

• Wheezing or an active hypersensitivity reaction at entry.
• Hypersensitivity to Aspergillus proteins.

Where it is running

• Stanford University — Palo Alto, California, United States
• Rady Children's Hospital — San Diego, California, United States
• Peyton Manning Children's Hospital at St. Vincent — Indianapolis, Indiana, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Children's Hospital Michigan — Detroit, Michigan, United States
• Columbia University Medical Center — New York, New York, United States
• Rhode Island Hospital — Providence, Rhode Island, United States
• St.Jude Children's Research Hospital — Memphis, Tennessee, United States
• Cook Children's Medical Center — Fort Worth, Texas, United States
• MD Anderson Cancer Center — Houston, Texas, United States
• Mid-West Children's Cancer Center — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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