Treatment of Nicotine Dependence and Acute Depression
Completed · Phase 4
Conditions studied: Major Depressive Disorder, Nicotine Dependence
In brief
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression. Participants who meet DSM-IV criteria for both nicotine dependence and acute major depression will be given pharmacological treatment for both disorders at the same time, along with a brief behavioral intervention for smoking cessation.
Key facts
- Study ID
- NCT00186446
- Run by
- Stanford University
- People needed
- 20
- Starts
- 2004-06-01
- Expected to finish
- 2007-09-01
- Last updated by the study team
- 2017-04-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age at least 18 at the beginning of the study
- Smoking at least 10 cigarettes a day (1/2 pack)
- Meets DSM-IV criteria for major depressive episode
You may not qualify if…
- Currently pregnant
- Currently breastfeeding
- Currently diagnosed with a seizure disorder, liver disease, kidney disease, congestive heart failure or diabetes mellitis
- History of a seizure, seizure disorder, significant head trauma or central nervous system tumor
- Family history of seizures
- Currently using intravenous drugs
- Currently using any drugs (marijuana, alcohol, cocaine, opiates, stimulants, etc.) on a daily basis
- Currently using any over-the-counter stimulants and anorectics (diet pills)
- Currently on fluoxetine (Prozac), bupropion (Wellbutrin, Wellbutrin SR, Wellbutrin XL) or any other antidepressants, monoamine oxidase inhibitors, antipsychotics, benzodiazepines, theophylline, systemic steroids or levodopa
- Currently on NRT or bupropion (Zyban)
- Current or past diagnosis of anorexia nervosa
- Previous allergic response to fluoxetine, bupropion, or NRT
- Previous failed quit attempt using NRT and bupropion in combination
- Current suicidal ideation
- Current or past psychosis, mania/hypomania, or any other Axis I or Axis II psychiatric diagnosis other than major depression and nicotine dependence
Where it is running
- Stanford University School of Medicine — Stanford, California, United States
Full record on ClinicalTrials.gov
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