Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis

Completed

Conditions studied: Sepsis, Relative Adrenal Insufficiency

In brief

The purpose of this pilot study is to (1) examine the changes in gene expression in patients who suffer from severe sepsis and whose shock (inadequate oxygen delivery to vital organs) state does not respond to fluid and vasopressor administration, (2) to show that our sampling method of isolating RNA provides reliable and consistent data, (3) provide a basis for future gene expression studies in critically ill patients

Key facts

Study ID

NCT00185783

Run by

Stanford University

People needed

10

Starts

2005-03-01

Expected to finish

2006-11-01

Last updated by the study team

2011-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission Diagnosis of Sepsis
• Evidence of Relative Adrenal Insufficiency
• Hypotension (Mean Arterial Pressure less than 60 mm Hg) Refractory to a. Fluid Resuscitation b. Dopamine infusion (greater than 5 micrograms/kg/min) c. Phenylephrine infusion (greater than 1 microgram/kg/min)

You may not qualify if…

• Use of Immunosuppressant Medications
• Immune Compromised Due to Disease (e.g., HIV infection)
• Transfusion of Blood Products within the past 7 Days
• Use of Cytokine Therapy (i.e., G-CSF)
• History of Bone Marrow Transplantation

Where it is running

• Stanford University Medical Center — Stanford, California, United States

Full record on ClinicalTrials.gov

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