Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia Refractory to Chemotherapy

Stopped early · Phase 1/Phase 2

Conditions studied: Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia

In brief

This study is for patients with non-hodgkin's lymphoma or chronic lymphocytic leukemia, which has failed to shrink or has returned after previous treatment with chemotherapy. The purpose of this study is to find out whether patients with these types of cancer will have their tumor shrunk after treatment with a drug called Noscapine. The second purpose is to see what are the side effects of this drug. This drug is being used as an over-the-counter cough suppressor in Europe and Japan, but has also shown to be effective against cancer.

Key facts

Study ID

NCT00183950

Run by

University of Southern California

People needed

12

Starts

2000-03-01

Expected to finish

2006-12-01

Last updated by the study team

2014-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with low grade NHL (follicular lymphoma, small cell lymphocytic lymphoma, marginal cell lymphoma, monocytoid B-cell lymphoma, MALT lymphoma, plasmacytoid lymphocytic lymphoma) or chronic lymphocytic leukemia who have demonstrated chemotherapy resistance (have not achieved CR,CRu, PR)or who have relapsed at any time following a response (CR, CRu, PR) after at least one therapy regimen, including chemotherapy, Rituximab, or high dose chemotherapy with stem cell rescue.
• Karnofsky performance status 60 % or greater.
• Creatinine less or equal to 2.0 mg/dl, bilirubin less or equal to 2.0 mg/dl, SGPT/SGOT less or equal to 4 x upper normal range

You may not qualify if…

• Patients with unconfirmed complete response(CRu)after last treatment and who currently remain in CRu.
• Pregnant or lactating women.
• Disease-specific treatment less than 1 month prior to starting this study.
• CNS disease.
• HIV-positive patients.
• Other cancer, except basal cell or squamous cell cancer of the skin or carcinoma in-situ of cervix.

Where it is running

• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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