Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users

Completed · Phase 3

Conditions studied: HIV Infections, Depression, Substance-Related Disorders

In brief

This study will evaluate the effectiveness of combining cognitive behavioral therapy (CBT) and antidepressants in reducing HIV risk behavior and drug relapse rates in depressed intravenous drug users.

Key facts

Study ID

NCT00183768

Run by

Butler Hospital

People needed

175

Starts

1999-09-01

Expected to finish

2003-02-01

Last updated by the study team

2013-08-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV criteria for major depression, dysthymia, substance-induced major depression, or major depression plus dysthymia
• Score of greater than 14 on the Hamilton Depression Rating Scale
• Involved in HIV risk behaviors
• Current opiate or cocaine use
• Basic proficiency in English

You may not qualify if…

• Current suicidal risk or ideation
• Current psychotic symptoms
• Simultaneous medical disorder that might make psychopharmacological treatment medically inadvisable
• History of bipolar disorder, schizophrenia, schizo-affective disorder, schizophreniform disorder, or paranoid disorder
• Currently taking other medications for depression

Where it is running

• Rhode Island Hospital — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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