Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults

Completed · Phase 4 · Has a placebo group

Conditions studied: Depression

In brief

This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or cardiopulmonary condition.

Key facts

Study ID

NCT00183729

Run by

Eric Lenze

People needed

35

Starts

2005-08-01

Expected to finish

2009-06-01

Last updated by the study team

2018-01-17

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to a skilled nursing facility for rehabilitation within 3 months of recent disabling medical event (e.g., hip fracture)
• Medically stable (e.g., no active seizures, delirium, unstable pulse/blood pressure)

You may not qualify if…

• Aphasia or cognitive impairments sufficiently severe to prevent valid assessment (e.g., a score of less than 22 on the Mini Mental State Examination)
• Current major depressive episode
• History of or current psychosis or mania
• Current substance or alcohol abuse or dependence (within 3 months of study entry)
• Current use of memantine
• Sensitivity or contraindication to memantine
• End-stage kidney, liver, heart, or lung disease
• Recent hemorrhagic stroke
• A FIM score of greater than 70 (on a 91 point scale)

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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