Prazosin for Treating Noncombat Trauma Post-Traumatic Stress Disorder
Stopped early · Not applicable · Has a placebo group
Conditions studied: Post-Traumatic Stress Disorder, Sleep Initiation and Maintenance Disorders
In brief
This study will evaluate the effectiveness of prazosin in treating post-traumatic stress disorder caused by noncombat trauma in individuals taking selective serotonin reuptake inhibitors.
Key facts
- Study ID
- NCT00183430
- Run by
- Seattle Institute for Biomedical and Clinical Research
- People needed
- 20
- Starts
- 2003-10-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2018-06-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnosis of PTSD, as derived from the Clinician-Administered PTSD Scale (CAPS)
- Stabilized on any necessary medications for at least 4 weeks prior to study entry
- Score of greater than 4 on the CAPS Recurrent Distressing Dreams item (maximum score of 8)
- Score of greater than 4 on the CAPS Difficulty Falling or Staying Asleep item (maximum score of 8)
- Agrees to use an effective form of contraception throughout the study
You may not qualify if…
- Any acute or significant chronic medical illness
- Any unstable medical condition
- Unstable angina, recent heart attack, history of congestive heart failure, pre-existing hypotension (systolic blood pressure less than 110 mm Hg), or orthostatic hypotension
- Insulin-dependent diabetes
- Chronic kidney or liver failure
- Pancreatitis or gout
- Meniere's disease, benign positional vertigo, or narcolepsy
- Allergy or previous adverse reaction to prazosin or other alpha-1 antagonist
- Currently taking another alpha-1 antagonist agent
- Pregnant
- DSM-IV diagnosis of cognitive disorder, schizophrenia, schizoaffective disorder, bipolar disorder, or other psychotic disorder
- Current delirium
- Active substance dependence disorder within 3 months of study entry
- Current substance use other than alcohol (no more than 2 drinks per day)
- Severe psychiatric instability or situational life crises, including evidence of suicidal or homicidal ideation
- Currently taking any other psychotropic medication (e.g., antidepressants, benzodiazepines, anti-convulsants, anti-psychotics, sedating antihistamines, sedatives/hypnotics (exclusionary medications will be discontinued and participants will undergo a 2-week washout period before baseline assessments)
Where it is running
- VA Puget Sound Health Care System — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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