Dietary Energy Restriction and Metabolic Aging in Humans
Completed · Not applicable
Conditions studied: Obesity
In brief
The purpose of this study is to develop an effective calorie restricted diet.
Key facts
- Study ID
- NCT00183027
- Run by
- National Institute on Aging (NIA)
- People needed
- 44
- Starts
- 2002-11-01
- Expected to finish
- 2004-12-01
- Last updated by the study team
- 2006-11-09
Who can join
Age: 20 and older, up to 42. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy men and women (based on standard laboratory tests and a screening examination)
- 20-42 years of age
- BMI in the range 25-29.9 kg/m2
- Proportional representation of minorities in the Greater Boston Area (7 percent Black, 11 percent Hispanic, 82 percent non-Hispanic white)
- Able to accurately complete a food record
- Stage of change >1 for weight loss and changing dietary intake
- Must have an immediate adult family member who is supportive of weight loss
You may not qualify if…
- Known serious disorders that affect longevity, energy metabolism, body composition and immune responsiveness, including diabetes, cancer, heart disease, cachexia, eating disorders (anorexia and bulimia and any vomiting for means of weight control), depression, alcoholism, inflammatory disorders and AIDS, and individuals taking medicine that is anticipated to influence lifespan or energy metabolism
- Abnormal kidney function as assessed by serum creatinine, BUN and urinalysis, and abnormal liver function as assessed by SGPT, SGOT alkaline phosphatase, and bilirubin, abnormal normal thyroid function as assessed by serum T4 and TSH and fasting serum glucose levels <125 mg/dl
- Smoking, highly restrained eating, reported endurance training (participation in sports or training >12 hours per week), alcohol intake of 14 oz. per week or more, major medical and/or psychiatric disorders, plans to have a child within 3 years (1 year for Pilot study), past childbearing (for women) within the last 2 years, or breastfeeding within the past year
- Amputees
- Have required treatment for any psychiatric disorder
- Gained or lost >15 lb weight within the past year, or taking medications known or suspected to have an important influence on lifespan, energy metabolism, body composition or immune function
- Early death from cardiovascular diseases, cancer, or a diabetes-related illness (before the age of 45 years) in one or both of the parents
- Unable to remain in the program for at least 1 year, or unsuitable for home-based programs (including individuals reporting binge eating disorders or clinical depression, and women intending to become pregnant)
Where it is running
- Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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