Donepezil in Preventing Delirium in Hospitalized Elderly

Completed · Phase 4

Conditions studied: Postoperative Complications, Delirium

In brief

The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.

Key facts

Study ID

NCT00182884

Run by

Indiana University Health

People needed

30

Starts

2004-07-01

Expected to finish

2007-04-01

Last updated by the study team

2008-03-03

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Community-dwelling individuals aged 65 or older
• Admitted to Methodist Hospital for surgical repair of hip fracture
• No evidence of delirium at admission to hospital
• MMSE total score below 24 points after adjustment for education and age
• Consent to participate in the study

You may not qualify if…

• Severely demented as defined by MMSE score below 10
• Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to under 6 months
• Multiple trauma or pathological fractures
• Aphasic, legally blind, or deaf
• Use of Donepezil or other cholinesterase inhibitors within one month prior to surgery
• Allergy to Donepezil

Where it is running

• Methodist Hospital, Clarian Health Partners — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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