Study of Glutamate and Glutamine Metabolism in Burn Patients Receiving Enteral or Parenteral Nutrition
Withdrawn before enrolling · Not applicable
Conditions studied: Burns
In brief
The purpose of the study is to understand how the body uses amino acids in burned patients during the time they cannot eat normally. Amino acids occur naturally in the body and the food we eat. The body combines amino acids to make protein. It uses the proteins to do things such as heal wounds, fight infection, and provide energy. We are studying two ways of receiving nutrition: through a vein or through a tube. We are also studying two different types of food: with or without glutamine. The results of this study will be used to determine the best type and way to supply nutrients during a severe burn injury. We hope to learn how to help the body use nutrients more efficiently to better repair wounded tissues and recover earlier from injury.
Key facts
- Study ID
- NCT00181753
- Run by
- Massachusetts General Hospital
- People needed
- 0
- Starts
- 2009-11-01
- Expected to finish
- 2010-10-01
- Last updated by the study team
- 2017-01-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- One or more of the following:
- 5% Total Body Surface Area Thermal Burn
- Inhalation Injury
- Resting Energy Expenditure of >15% of the predicted Basal Metabolic Rate Using Harris-Benedict.
- Receiving Enteral or Parental Nutritional Support
You may not qualify if…
- Pre-existing:
- Thyroid disease
- Congestive Heart Failure (Ejection fraction <20%)
- Malignancy currently under treatment
- Medical conditions requiring glucocorticoid treatment
- Decision not to treat because of severity of injury
- Presence of Anoxic brain injury with no expectation for recovery
- Self-Inflicted thermal injury
- Ileus, gut paralysis, or facial injuries
- No NG or OG tube as part of their clinical care
Where it is running
- Massachusetts General Hospital Burn Unit — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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