Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Recruiting now

Conditions studied: Heart Failure, Congestive

In brief

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Key facts

Study ID

NCT00181259

Run by

Johns Hopkins University

People needed

500

Starts

1988-01-01

Expected to finish

2028-08-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age > 18 years
• Healthy subjects: no history of heart disease
• Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) <40%
• Left ventricular hypertrophy: wall thickness >1.2cm
• Coronary artery disease: >50% coronary lesion or positive stress test

You may not qualify if…

• contraindication to MRI

Where it is running

• Johns Hopkins Medical Institutions — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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