Assessment of Metabolic Response in Critically Ill Patients With Acute Renal Failure

Stopped early · Phase 2

Conditions studied: Acute Renal Failure

In brief

We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to critically ill patients with acute renal failure (ARF).

Key facts

Study ID

NCT00179166

Run by

Vanderbilt University

People needed

3

Starts

2004-06-01

Expected to finish

2005-07-01

Last updated by the study team

2010-09-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥ 18 years of age admitted to the intensive care unit
• New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease
• ARF will be defined by a sustained (over 24 hours) increase in serum creatinine > 0.5 mg/dl from baseline
• Patients will be recruited for the study within 3-5 days following establishment of ARF

You may not qualify if…

• Institutionalized patient
• Previous kidney transplant
• Pregnancy
• Unable to obtain consent from subject or legally recognized representative
• ARF from urinary tract obstruction or a volume responsive pre-renal state.
• Liver Failure
• Recent cerebrovascular accident (CVA)
• Coagulopathy defined as: Platelets < 50, PT > 20, INR > 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion.
• Life expectancy < 48 hours

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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