AMP as a Better Delivery System of Adenosine
Stopped early · Phase 1
Conditions studied: Ischemia
In brief
Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks. The problem in using adenosine is that it is taken up by cells and, therefore, very little of the adenosine we give by vein or in the artery actually reaches the tissue. We propose to use AMP as a way to improve delivery of adenosine. AMP is inactive by itself, but is converted to adenosine in tissue. We hope that by giving AMP we will increase levels of adenosine in tissue. To see if this is true, we will give either adenosine or AMP into the forearm artery while we measure how much adenosine reaches the forearm tissue.
Key facts
- Study ID
- NCT00179010
- Run by
- Vanderbilt University Medical Center
- People needed
- 13
- Starts
- 2003-10-01
- Expected to finish
- 2017-01-01
- Last updated by the study team
- 2019-05-07
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteers
- Age 18-65
- Non smokers
You may not qualify if…
- Smokers
- Any chronic disease
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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