Hyperthermia/Thermal Therapy With Chemotherapy to Treat Inoperable or Metastatic Tumors

Status unconfirmed · Phase 2

Conditions studied: Neuroendocrine Cancer, Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Gastric Cancer

In brief

Thermal therapy (hyperthermia, or heat) increases chemotherapy cancer cell kill. By itself, thermal therapy can also kill cancer cells. Whole body thermal therapy is a systemic treatment; whole-body fever-range thermal therapy can safely treat cancer cells wherever they are throughout the entire body. In this study, we are testing the combination of fever-range heat treatment and chemotherapy to test 1) The response of three types of cancer (small-cell lung, neuroendocrine cancer, lung cancer, and gastric cancer) to the thermo-chemotherapy improves cancer response compared to the effect of only chemotherapy drugs in current use; 2) whether the thermo-chemotherapy treatment helps the person's own body fight the cancer cells; and 3) whether this treatment is safe and comfortable for the patient. This study does not offer heat treatment alone. Any patient with inoperable or metastatic small cell lung cancer, neuroendocrine cancer (any organ), gastric cancer, or lung cancer, can be treated with the Phase II protocol therapy; however, the patient will need to undergo selected medical tests to make sure this treatment would be safe for them.

Key facts

Study ID

NCT00178698

Run by

The University of Texas Health Science Center, Houston

People needed

36

Starts

2002-07-01

Expected to finish

2014-06-01

Last updated by the study team

2011-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient with inoperable or metastatic small-cell lung cancer, neuroendocrine cancer (any organ), gastric cancer, of lung cancer are eligible for protocol treatment.
• However the patient:
• Must not have metastasis to the brain
• Must be able to achieve positive results on preliminary tests
• Must have a good ECOG performance status

You may not qualify if…

• Metastasis to the brain
• Poor results on preliminary physiological tests
• a Poor ECOG performance status score

Where it is running

• Memorial Hermann Hospital — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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