Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)

Completed

Conditions studied: Brain Injuries, Traumatic, Traumatic Brain Injury

In brief

The specific aim of this research is to determine if the blood from brain-injured patients contains reproducible protein markers that appear prior to elevations in intracranial pressure (ICP).

Key facts

Study ID

NCT00178659

Run by

The University of Texas Health Science Center, Houston

People needed

260

Starts

2004-08-25

Expected to finish

2026-06-08

Last updated by the study team

2026-06-16

Who can join

Age: 14 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 14-65 years old
• Non-penetrating brain injury
• ICP monitor or
• Healthy volunteer or
• The orthopedic injury cohort will include patients admitted to the ED able to provide informed consent with the following:
• Fracture confirmed radiographically
• No head trauma
• No other known inflammatory process or infection
• No history of neurological or psychiatric disorders or alcohol or drug dependency.
• or The mild TBI patients will be defined as those experiencing,
• Non-penetrating head trauma manifesting one or more of the following:
• Loss of consciousness
• Post-traumatic amnesia
• Altered mental status
• Focal neurologic deficits, seizure
• GCS> 12
• No abnormalities on CT other than contusion
• No operative Lesions
• Length of hospital stay < 48 hrs
• No other known inflammatory process or infection
• No history of neurological or psychiatric disorders or alcohol or drug dependency

You may not qualify if…

• Inability to obtain informed consent

Where it is running

• The University of Texas, Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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