Enteral Glutamine Supplementation for the Patient With Major Torso Trauma

Stopped early · Phase 1

Conditions studied: Trauma, Critical Illness, Shock

In brief

Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.

Key facts

Study ID

NCT00178581

Run by

The University of Texas Health Science Center, Houston

People needed

20

Starts

2005-06-01

Expected to finish

2006-09-01

Last updated by the study team

2010-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult trauma patients meeting criteria for shock resuscitation
• Major torso trauma
• Admission to the Shock/Trauma Intensive Care Unit

You may not qualify if…

• Age <18 years
• Pregnant
• Expected survival < 24 hours
• Bowel in discontinuity
• Renal failure: baseline serum creatinine>3.0 and/or dialysis
• Admission total bilirubin >10 mg/dl
• History of cirrhosis or cirrhosis apparent on exploratory laparotomy
• Asystole or CPR required

Where it is running

• University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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