Vitamin E and Male Infertility

Completed

Conditions studied: Male Infertility

In brief

The goal of this study is to determine whether there is a correlation between the levels of Vitamin E in sperm and sperm DNA fragmentation. Previous research has shown that damage to the DNA in sperm may cause infertility or increase the chances of miscarriage, if the damage is extensive (eg. present in the overwhelming majority of sperm). Some studies suggest that DNA damage can be caused by oxidative stress. Antioxidants, such as Vitamin E, which are present in some foods, can prevent damage to cells from "free radicals", which are naturally present by-products of metabolism. We ask whether there is a correlation between sperm DNA damage and Vitamin E

Key facts

Study ID

NCT00178516

Run by

University of Rochester

People needed

58

Starts

2004-06-01

Expected to finish

2005-12-01

Last updated by the study team

2009-07-30

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• infertile men with previously abnormal semen analyses.
• Control group: fertile adult males

You may not qualify if…

• Proxceed use within 3 months of the start of study.
• Vitamin E supplements with > 45 IU daily

Where it is running

• University of Rochester Medical Center, Department of OB/GYN — Rochester, New York, United States

Full record on ClinicalTrials.gov

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