Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children
Completed · Phase 1
Conditions studied: Hypertension
In brief
High blood pressure, or hypertension, affects up to 10% of minority children and adolescents. Although complications of high blood pressure, such as stroke and heart attack, are uncommon in childhood, high blood pressure-related organ damage can occur at a young age. Studies with young adults have indicated that high blood pressure can affect the central nervous system, resulting in deficits in brain function. However, more research is necessary to confirm the association between neurocognitive deficits and high blood pressure in children and to determine if these deficits are reversible with treatment. This study will determine whether high blood pressure in children and adolescents has subtle effects on learning, attention, and concentration. The study will also determine the effect of an antihypertensive treatment plan, involving a combination of diet, weight loss, increased exercise, and if needed, blood pressure medication, on brain function in children and adolescents receiving treatment for high blood pressure.
Key facts
- Study ID
- NCT00178490
- Run by
- University of Rochester
- People needed
- 100
- Starts
- 2005-01-01
- Expected to finish
- 2010-01-01
- Last updated by the study team
- 2014-06-04
Who can join
Age: 10 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- English speaking
- No known learning disorder, disorders of cognitive function, treatment with medications for attention deficit, or history of severe head injury (loss of consciousness for more than 30 minutes)
- Casual blood pressure greater than or equal to 90th percentile for age, gender, and height during clinic visit and on at least two other previous occasions
You may not qualify if…
- Secondary cause of high blood pressure
- Chronic disease
- History of treatment for elevated lead level
- History of maternal substance use during pregnancy
- Evidence of obstructive sleep apnea
Where it is running
- University of Rochester, Strong Memorial Hospital — Rochester, New York, United States
Full record on ClinicalTrials.gov
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