Determining Changes in Brain Structure Associated With Symptoms of Late-life Depression

Completed

Conditions studied: Late-Life Depression

In brief

This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression.

Key facts

Study ID

NCT00178087

Run by

University of Pittsburgh

People needed

331

Starts

2005-08-01

Expected to finish

2011-08-01

Last updated by the study team

2015-04-07

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of a mood disorder

You may not qualify if…

• Major acute medical illnesses or injuries known to have significant direct effects on cognitive functioning (e.g., metastatic cancer, multiple sclerosis, traumatic brain injury).
• Uncorrectable sensory handicap (e.g., blindness), because they are unable to complete the cognitive test battery.
• Exclusion criteria for MR scans include: cardiac pacemaker, aneurysm clip, cochlear implant, pregnancy, IUD, shrapnel, history of metal fragments in the eye, neurostimulators, weight of 250 lbs. or more, or claustrophobia.

Where it is running

• UPMC Late-Life Evaluation and Treatment Center — Pittsburgh, Pennsylvania, United States
• UPMC Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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