The Effects of Sleep Deprivation on Antidepressant Response

Completed · Phase 4

Conditions studied: Unipolar Depression

In brief

This study will use positron emission tomography (PET) to examine the effect of sleep deprivation on brain function.

Key facts

Study ID

NCT00178074

Run by

University of Pittsburgh

People needed

80

Starts

1999-02-01

Expected to finish

2003-04-01

Last updated by the study team

2013-08-02

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients:
• DSM-IV criteria for current major depressive disorder
• Score of 15 or higher on the HRSD (17 item)
• Score of 17 or higher on the Folstein Mini-Mental Status Exam
• Control Subjects:
• No history of psychiatric disorder or neurological illness

You may not qualify if…

• Patients:
• lifetime diagnosis of any psychotic disorder
• bipolar disorder
• alcohol or drug abuse within the last 6 months
• No contraindication to SSRI therapy
• History of seizure disorder
• Both Patient and Control Subjects:
• Current diagnosis of diabetes or significantly altered plasma glucose levels

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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