Sleep Deprivation Plus Paroxetine for Treating Major Depression in Elderly Individuals

Completed · Phase 4

Conditions studied: Depression

In brief

This study will determine the effectiveness of total sleep deprivation (TSD) for one night plus paroxetine versus either TSD plus placebo or paroxetine alone in inducing rapid symptom resolution of major depression in the elderly.

Key facts

Study ID

NCT00178035

Run by

University of Pittsburgh

People needed

158

Starts

1999-12-01

Expected to finish

2003-08-01

Last updated by the study team

2013-08-02

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 60 and older
• Current episode of unipolar, major depression
• HRSD (17 item)score of 15 or higher
• Folstein Mini-Mental Status exam score of 17 or higher

You may not qualify if…

• Lifetime diagnosis of any psychotic disorder
• Lifetime diagnosis of bipolar disorder
• _Alcohol or drug abuse within the past 6 months
• Contraindication to treatment with SSRI therapy
• History of seizure disorder
• Baseline apnea/hypopnea index of 20 or higher
• Hyponatremia

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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