Pharmacodynamic Parameters of Two Different Doses of Cefepime
Completed
Conditions studied: Infection, Bacteremia, Pneumonia
In brief
Pharmacokinetics is the study of the disposition of drugs in the body, while pharmacodynamics considers the interaction of the drug at the site of infection over time. Mathematical models of antibiotic pharmacodynamics are sometimes used to predict if antibiotic doses are sufficient to treat infection with organisms of different minimal inhibitory concentrations of the antibiotic. Based on these models, there has been speculation that the antibiotic cefepime dosed at one gram every 12 hours, is insufficient to kill all organisms within the "susceptible" range. This study of patients treated with cefepime will involve the collection of blood to determine cefepime concentrations, and determine if those concentrations are effective in killing the bacteria at the site of infection.
Key facts
- Study ID
- NCT00177736
- Run by
- University of Pittsburgh
- People needed
- 180
- Starts
- 2005-09-01
- Expected to finish
- 2007-12-01
- Last updated by the study team
- 2007-12-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults of at least 18 years of age or older
- Culture proven ventilator associated pneumonia (VAP) or bacteremia caused by a cefepime susceptible gram negative pathogen:
- Bacteremia is defined as at least one positive blood culture
- VAP is defined by at least 10,000 cfu/ml of an organism from a bronchoalveolar lavage sample
- Cefepime therapy (1 or 2 grams intravenously [IV] every [q] 8 hours or q 12 hours) initiated as part of standard of care
You may not qualify if…
- Concomitant VAP or bacteremia with a cefepime resistant organism
- Concomitant therapy with an antimicrobial agent active against gram negative bacilli other than a single dose of aminoglycoside
- Patients requiring surgical or interventional drainage of purulent collections
- Pregnant or lactating women
- Dialysis patients
- Contraindication to blood sampling
- Cystic fibrosis
Where it is running
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.