Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin
Completed · Phase 4
Conditions studied: Schizophrenia, Schizoaffective Disorder
In brief
This study supplements patients' current medications with Pravastatin, a cholesterol-lowering medication, to try to improve residual symptoms of schizophrenia, and also to improve cognitive functioning.
Key facts
- Study ID
- NCT00177580
- Run by
- University of Pittsburgh
- People needed
- 72
- Starts
- 2003-07-01
- Expected to finish
- 2007-07-01
- Last updated by the study team
- 2008-01-15
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of schizophrenia or schizoaffective disorder
- Male and female subjects; age 18-65 years inclusive
- Ability to provide informed consent
- No psychiatric hospitalization in the last 30 days prior to randomization
- PANSS score at study entry between 80 and 120 inclusive, OR those who continue to experience some residual positive and/or negative symptoms and are not at their baseline level of functioning.
- Current psychiatric medications stable for at least 30 days
- Currently receiving only one antipsychotic medication
- Female subjects of child-bearing age must use an acceptable method of birth control
You may not qualify if…
- Active, uncontrolled, or chronic liver disease
- Heart failure
- Current alcohol abuse or dependence
- Female subjects who are pregnant, lactating or plan to become pregnant during the study period
- History of allergic reaction with any statin in the past
- Kidney disorder or other evidence of renal dysfunction
- Uncontrolled diabetes
- Untreated hyperlipidemia
- Concurrently receiving treatment with cyclosporine, gemfibrozil, clofibrate, fenofibrate, niacin, macrolide antibiotics, erythromycin, HIV protease inhibitors, nefazodone, or verapamil
Where it is running
- Western Psychiatric Institute & Clinic — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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