Mifepristone and Misoprostol for Fetal Demise
Completed · Phase 4
Conditions studied: Anembryonic Pregnancy, Gestation Abnormality, Intrauterine Fetal Demise Term
In brief
This is a pilot clinical trial to evaluate whether the medical management of early pregnancy failure with mifepristone and misoprostol is an effective and acceptable treatment. Subjects with early pregnancy failure receive mifepristone followed 24 hours later by vaginal misoprostol for medical management. Subjects then return on study day 3 for a repeat ultrasound to assess passage of pregnancy tissue. subjects who still have a gestational sac present at Day 3 receive a second dose of vaginal misoprostol. All subjects have a follow-up at Day 15, by phone for those who passed the pregnancy with the first dose of misoprostol, and in person for those who received a second dose. Questionnaires are administered at the beginning and end of the study to determine acceptability.
Key facts
- Study ID
- NCT00177372
- Run by
- University of Pittsburgh
- People needed
- 30
- Starts
- 2005-01-01
- Expected to finish
- 2005-09-01
- Last updated by the study team
- 2016-01-29
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may not qualify if…
- orthostatic hypotension, contraindication to either mifepristone or misoprostol, treatment during current pregnancy to provide surgical or medical evacuation of the uterus, evidence of ovarian hyperstimulation syndrome, known or suspected pelvic infection,known or suspected clotting defect or receiving anticoagulants, cardiovascular disease, current breastfeeding, pregnancy with and IUD in situ, current participation in another clinical trial, prior participation in this trial, suspected or confirmed endometrial AV malformation, clinical indication requiring the karyotyping of products of conception
Where it is running
- Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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