Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression

Completed · Phase 4

Conditions studied: Depression

In brief

This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.

Key facts

Study ID

NCT00177294

Run by

University of Pittsburgh

People needed

319

Starts

2004-04-01

Expected to finish

2009-08-01

Last updated by the study team

2012-01-12

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of unipolar major depression
• Hamilton Rating Scale for Depression (HRSD) (17 item) score of 15 or higher
• Speaks English
• Willing to discontinue other psychotropic medications
• Availability of family member or other caregiver
• Hearing capacity adequate to respond to a raised conversational voice

You may not qualify if…

• Lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any psychotic disorder
• Folstein Mini-Mental Status Exam (MMSE) of 17 or lower
• Suicidal
• History of treatment non-adherence in other Center protocols
• History of documented non-response to citalopram in other Center protocols
• History of non-tolerance to escitalopram therapy

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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