In Vitro Evaluation of Immune Responses in Cutaneous T-Cell Lymphoma (CTCL)

Completed

Conditions studied: Cutaneous T-cell Lymphoma, Sezary Syndrome, Mycosis Fungoides

In brief

This is an in vitro evaluation of cutaneous T-cell lymphoma using patients' blood and tissue to evaluate immune responses related to identified tumor populations and dendritic/CD 8 cells.

Key facts

Study ID

NCT00177190

Run by

University of Pittsburgh

People needed

8

Starts

2002-06-01

Expected to finish

2006-01-01

Last updated by the study team

2014-05-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females <18 years of age
• Histologically confirmed stage IV cutaneous T-cell lymphoma, with at least 5% of the peripheral blood lymphocytes showing atypical morphology consistent with Sezary cells
• Ambulatory and be in stable medical condition
• Biopsy positive mycosis fungoides/CTCL or clonal type of CTCL as determined by PCR for TCR and Southern blot for TCR

You may not qualify if…

• Received any chemotherapy or radiotherapy within 4 weeks prior to enrollment
• Significant psychiatric illness which would prevent adequate informed consent in the opinion of the principal investigator
• Systemic steroid therapy other than maintenance for adrenal suppression
• Known coagulopathy for non SS subjects.

Where it is running

• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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