Intraocular Pressure During Prone Spinal Surgery

Stopped early

Conditions studied: Spine Surgery, Vision Impairment

In brief

Postoperative visual loss resulting from surgical procedures not performed on the eye is a devastating outcome for the patient and poorly understood by the medical community. It is potentially a preventable complication. Diminished blood supply to the optic nerve, affecting both the anterior or posterior portions of the optic nerve, is the most common cause of postoperative visual loss. Other, less common causes include occlusion of the retinal artery and vein, a retinal embolism and cortical blindness. The incidence of postoperative visual loss increases in patients undergoing cardiopulmonary bypass and prone spinal surgery. Although the etiology of postoperative visual loss is unknown, it is thought to be multifactorial, and several potential risk factors have been identified, including degree of low blood pressure, preoperative hematocrit, external compression of the eye, amount of blood loss, prolonged duration of surgical time and lying in the face down position. The investigators believe this study is a unique opportunity to examine the mechanisms responsible for the antecedents to postoperative visual loss (POVL) and ischemic optic neuropathy (ION), a devastating complication of (usually) an elective surgical procedure. The purpose of this research is to try and determine the potential variables responsible for postoperative visual loss which will assist the medical community in devising methods for its prevention.

Key facts

Study ID

NCT00176722

Run by

University of Medicine and Dentistry of New Jersey

People needed

7

Starts

2006-06-01

Expected to finish

2012-01-01

Last updated by the study team

2015-04-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women between the ages of 18 and 65 years of age who are mentally capable of providing an informed consent.
• Planned elective spinal surgery in which the modified Jackson table will be used.

You may not qualify if…

• Failure to provide an informed consent
• History of stroke
• Known history of corneal disease
• Known history of carotid disease
• Known history of sensitivity to cyclogyl and/or proparacaine HCL 0.5%

Where it is running

• University of Medicine & Dentistry - New Jersey Medical School — Newark, New Jersey, United States
• University of Medicine & Dentistry of NJ — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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