The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon

Stopped early · Not applicable

Conditions studied: Aberrant Crypt Foci

In brief

The purpose of this study is to determine the effectiveness of curcumin in reducing the number of aberrant crypt foci (ACF) in the colon.

Key facts

Study ID

NCT00176618

Run by

University of Medicine and Dentistry of New Jersey

People needed

60

Starts

2004-04-01

Expected to finish

2007-06-01

Last updated by the study team

2009-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects must be eligible for colorectal cancer (CRC) screening/surveillance by current criteria.
• Subjects must have at least 5 ACF on eligibility chromosigmoidoscopy examination.

You may not qualify if…

• Subjects must not have:
• Alcohol consumption of greater than 2 glasses of wine or beer per day or illicit recreational drug use
• Platelet or coagulation abnormalities, or personal history of a bleeding disorder, including individuals taking warfarin.
• High risk for developing endocarditis (history of endocarditis or rheumatic fever, cardiac valve prostheses, or mitral valve prolapse that requires antibiotic prophylaxis).
• Uncontrolled hypertension, diabetes, or chronic congestive heart failure.
• Renal insufficiency defined as a serum creatinine > 2.5 mg/dl
• History of colorectal surgery with removal of the distal 60 cm of colon or rectum.
• History of other gastrointestinal mucosal epithelial diseases (such as Barrett's esophagus, chronic or recurrent peptic ulcer disease, celiac sprue or other disorders of nutrient absorption).

Where it is running

• Cancer Institute of New Jersey — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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