A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity

Stopped early · Not applicable

Conditions studied: Neurotoxicity Syndromes

In brief

The purposes of this study are to find out whether dextromethorphan can prevent the short or long-term neurologic side effects of methotrexate, and whether dextromethorphan can improve symptoms of short-term neurologic side effects if they do occur.

Key facts

Study ID

NCT00176553

Run by

University of Medicine and Dentistry of New Jersey

People needed

20

Starts

2003-03-01

Expected to finish

2007-05-01

Last updated by the study team

2009-12-11

Who can join

Age: 2 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed acute lymphocytic leukemia (ALL), non-Hodgkin's lymphoma (NHL) or OS. Patients will be separately stratified and randomized by disease.
• Patients with history of seizures are eligible but will be stratified separately.

You may not qualify if…

• Patients taking monoamine oxidase inhibitors (MAOIs) will be excluded from the study, because of the risk of severe drug interactions.
• Pregnant or lactating women.

Where it is running

• Cancer Institute of New Jersey — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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