A Comparison of Bupropion SR and Placebo for Smoking Cessation

Completed · Phase 4 · Has a placebo group

Conditions studied: Tobacco Use Disorder

In brief

The purpose of this study is to examine whether the adjunctive use of bupropion SR in the context of a psychoeducational program modified for people with schizophrenia might improve the likelihood of successful abstinence in this population. If bupropion SR is effective for reducing cigarette smoking, then it will be important to determine if decreased nicotine intake is associated with a worsening of psychotic, anxiety or depressive symptoms. In addition, it would be important to determine the effect that a reduction in nicotine stimulation would have on patient's cognitive functioning, as nicotinic receptors have been shown to regulate attention and memory function, and it is hypothesized that these functions are normalized by acute nicotine administration in people with schizophrenia

Key facts

Study ID

NCT00176449

Run by

University of Maryland, Baltimore

People needed

52

Starts

2001-04-01

Expected to finish

2005-12-01

Last updated by the study team

2019-08-16

Who can join

Age: 18 and older, up to 64. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Inclusion Criteria are:
• DSM-IV diagnosis of Schizophrenia or schizoaffective disorder
• Age: 18-64
• Regular half pack a day smokers
• Score of at least 4 on the Nicotine Dependency Test

You may not qualify if…

• Exclusion Criteria are:
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• Seizure disorders, other Neurologic illnesses, or a family history of seizures
• A medical condition that could manifest psychiatrically
• Currently experiencing a depressive episode
• Active substance abuse
• Currently receiving bupropion
• Pregnant women
• Children (<18 years of age)
• Two consecutive sodium levels of 130 mmol/L or less

Where it is running

• Maryland Psychiatric REsearch Center — Catonsville, Maryland, United States

Full record on ClinicalTrials.gov

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