A Study of the Safety and Effectiveness of Lyophilized Certolizumab Pegol in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis

Completed · Phase 3

Conditions studied: Rheumatoid Arthritis

In brief

An open ended study in which patients who completed the double-blind study CDP870-027 \[NCT00152386\] are given Certolizumab Pegol (CZP) and assessed for signs and symptoms of Rheumatoid Arthritis (RA).

Key facts

Study ID

NCT00175877

Run by

UCB Pharma

People needed

857

Starts

2005-06-01

Expected to finish

2012-02-01

Last updated by the study team

2020-03-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have either failed to achieve American College of Rheumatology 20 % Response Criteria (ACR20) at Weeks 12 and 14 in C87027 [NCT00152386], or must have completed the entire Week 52 assessment of C87027 [NCT00152386] trial.

You may not qualify if…

• A diagnosis of any other inflammatory Arthritis (e.g. Psoriatic Arthritis or Ankylosing Spondylitis)
• A secondary, non-inflammatory type of Arthritis (e.g. Osteoarthritis or Fibromyalgia) that in the Investigator's opinion is symptomatic enough to interfere with evaluation of the effect of CDP870 on the patient's primary diagnosis of Rheumatoid Arthritis
• Any concomitant biological therapy
• Any experimental therapy, within or outside a clinical trial

Where it is running

• 148 — San Diego, California, United States
• 153 — Danbury, Connecticut, United States
• 133 — Ocala, Florida, United States
• 140 — Orlando, Florida, United States
• 150 — Orlando, Florida, United States
• 145 — Sarasota, Florida, United States
• 136 — Tampa, Florida, United States
• 157 — Coeur d'Alene, Idaho, United States
• 155 — Springfield, Illinois, United States
• 134 — Wheaton, Maryland, United States
• 151 — St Louis, Missouri, United States
• 156 — Lincoln, Nebraska, United States
• 135 — Charlotte, North Carolina, United States
• 147 — Cleveland, Ohio, United States
• 158 — Dayton, Ohio, United States
• 139 — Charleston, South Carolina, United States
• 137 — Austin, Texas, United States
• 143 — San Antonio, Texas, United States
• 12 — Buenos Aires, Argentina
• 14 — Capital Federal, Argentina
• 1 — Capital Federal, Argentina
• 9 — Capital Federal, Argentina
• 8 — Ciudad Autonoma de Buenos Aire, Argentina
• 11 — Córdoba, Argentina
• 152 — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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