Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers

Completed · Not applicable

Conditions studied: Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases

In brief

The aim of this study is to explore the significance of the Lys:Arg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary Lys:Arg on cardiovascular disease risk factors and endothelial function.

Key facts

Study ID

NCT00175084

Run by

Tufts University

People needed

30

Starts

2004-10-01

Expected to finish

2012-12-01

Last updated by the study team

2014-05-23

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: 50-85 years
• LDL-C concentrations >120 mg/dL

You may not qualify if…

• Use of medications known to affect lipid metabolism
• Established cardiovascular disease
• Renal disease
• Liver disease
• Thyroid disease unless controlled with medication for at least 6 months
• Type I and II diabetes
• Irritable bowel syndrome
• Chronic use of prescription anti-inflammatory medications
• Smoking
• Alcohol intake >7 alcoholic drinks per week
• Unwillingness to maintain body weight during participation in the study
• triglyceride (TG) > 400 mg/dL
• Unwillingness to adhere to diet and study protocol
• Weight gain or loss of more than 15 lb within 6 months prior to enrollment

Where it is running

• Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.