The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.

Completed · Phase 3

Conditions studied: Heartburn, Dyspepsia

In brief

Investigate the role of tegaserod in modulating gastric sensitivity to mechanical distention of the stomach

Key facts

Study ID

NCT00171457

Run by

Novartis

People needed

24

Starts

2005-04-01

Expected to finish

2006-09-01

Last updated by the study team

2007-10-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female subjects at least 18 years of age.
• Subjects willing to undergo multiple nasogastric intubations.
• Patients with functional heartburn will need to meet ROME II criteria.
• Patients with symptoms consistent with dyspepsia (epigastric pain/discomfort characterized by bloating, postprandial fullness and early satiety)

You may not qualify if…

• Subjects with clinically significant diarrhea or a diagnosis of diarrhea-predominant IBS.
• Subjects with a diagnosis of IBD, Barrett's esophagus, esophageal stricture or ring, or previous or current history of ulcer disease.
• Subjects with Diffuse Esophageal Spasm or Achalasia.
• Other protocol-defined inclusion/exclusion criteria may apply.

Where it is running

• Oklahoma Foundation for Digestive Research — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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