Tuberculosis Immunity in Children
Completed
Conditions studied: Tuberculosis
In brief
The purpose of this study is to gain a better understanding of how immunity to tuberculosis (TB) is maintained in children. When children get tuberculosis, it is more likely to spread to other parts of the body than when adults get it. This study will compare the blood cells that fight TB in children to the blood cells that fight TB in adults. Children enrolled in this study will have blood drawn on 1 or 2 occasions. Adult participants will be leukapheresed, a process in which blood passes through a machine collecting specific blood cells and returning the remaining blood to the body. An estimated 260 subjects will be enrolled in this study.
Key facts
- Study ID
- NCT00170638
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 260
- Starts
- 2005-04-01
- Expected to finish
- 2010-04-01
- Last updated by the study team
- 2008-04-25
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Children:
- Diagnosed with latent Mtb infection (LTBI), localized tuberculosis (TB), or disseminated TB.
- Age less than or equal to 10 years.
- Adults:
- Diagnosed with localized TB or LTBI.
- All individuals with LTBI will be healthy.
- Individuals with localized TB will have been treated for TB for at least 1 month.
You may not qualify if…
- Older children 11-17 years old.
- Children who are immunocompromised.
- Immunocompromised adults.
- Pregnant women.
- Non-English or non-Spanish speaking individuals.
Where it is running
- Oregon Health Sciences University — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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