Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms
Completed · Not applicable
Conditions studied: Prodromal Schizophrenia, Psychotic Disorders
In brief
The Recognition and Prevention (RAP) Program is conducting a research study comparing an antidepressant, sertraline, alone versus in combination with a second-generation antipsychotic, risperidone, to evaluate their ability to reduce unusual thoughts, suspiciousness and other unusual experiences, to improve reasoning ability, memory, attention and social skills in adolescents.
Key facts
- Study ID
- NCT00169988
- Run by
- Northwell Health
- People needed
- 8
- Starts
- 2004-03-01
- Expected to finish
- 2007-04-01
- Last updated by the study team
- 2009-12-17
Who can join
Age: 12 and older, up to 22. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participants are between the ages of 12 and 22.
- Participants are English-speaking.
- Participants are experiencing one or more symptoms like unusual thoughts, suspiciousness, or unusual perceptual experiences.
- Participants meet additional RAP criteria (evaluated during screening and interview).
You may not qualify if…
- Participants have been diagnosed with an Axis I psychotic disorder, including: schizophreniform disorder, schizophrenia, schizoaffective disorder, bipolar disorder, or major depression with psychotic features.
- Participants have a history of neurological, neuroendocrine, or other medical conditions known to affect the brain.
- Participants have a medical condition that contraindicates treatment with sertraline or risperidone.
- Participants have past or current substance dependence.
- Participants are currently taking and responding well to antidepressant or antipsychotic medication
Where it is running
- RAP Program, Dept. of Psychiatry Research, The Zucker Hillside Hospital — Glen Oaks, New York, United States
Full record on ClinicalTrials.gov
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