Renogram Study With Percutaneous Nephrolithotomy (PERC): Alterations in Renal Blood Flow as a Consequence of PERC
Completed · Not applicable
Conditions studied: Renal Calculi
In brief
Patients with large or otherwise complex renal calculi are commonly treated by percutaneous nephrolithotomy (PNL; PERC). PERC requires the creation of an approximately 10 mm channel through the renal parenchyma, into the intra-renal collecting system, in order to effect stone fragmentation and extraction. Although the nephrostomy tract is confined to a small fraction of the renal parenchyma (approximately 1%), the trauma associated with the creation of the tract will affect blood flow and oxygen delivery to regions beyond the immediate site of injury. It is possible that this could result in a significant functional renal impairment. There are several reports describing the effect of PERC on renal function, but interpretation of these studies is difficult, due to a lack of uniformity in patient selection and variability in the timing of peri-operative evaluation. Recent data from the investigators' lab, obtained from a porcine model, suggest that, acutely, PERC causes a significant decrease in renal function as measured by para amino hippurate (PAH) clearance. The purpose of this study is to determine, in a rigorous and standardized fashion, the acute effects of PERC on renal function, as measured by nuclear renography.
Key facts
- Study ID
- NCT00169741
- Run by
- Indiana Kidney Stone Institute
- People needed
- 4
- Starts
- 2005-05-01
- Expected to finish
- 2016-02-01
- Last updated by the study team
- 2016-02-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients of Methodist Urology in Indianapolis, IN
- Age greater than 18 years
- Ability to provide informed consent
- Unilateral renal calculi appropriate for percutaneous removal
You may not qualify if…
- Age less than 18
- Inability to give informed consent
- Pregnant
- Renal calculi associated with infection
- Serum creatinine > 1.4 mg/dL
- Renal obstruction
- Renal anatomic abnormality precluding accurate functional assessment using nuclear medicine techniques
- Renal duplication/anatomic abnormality (e.g., horseshoe kidney, malrotation, ectopia, etc.)
- Pre-existing diuretic therapy
- Solitary functional kidney or suspected significant differential in renal function
- Presence of diabetes, hypertension, or any other systemic disorder or medication known to affect renal function
- History of urinary tract infection
Where it is running
- IU Health Methodist Hospital — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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