Epidemiology and Care of Comorbid Obesity and Depression

Completed · Not applicable

Conditions studied: Obesity, Depression

In brief

We propose to: * Conduct cross-sectional assessments of depression, disability, health-related quality of life, eating patterns, and eating attitudes in a population-based sample approximately 6000 women aged 40-60 with over-sampling of women with BMI greater than 30 kg/m2. * Among obese women free of depression, enroll approximately 100 in a 6-month standard behavior therapy weight management program. * Among obese women with significant depression, randomly assign 200 to either a 6-month standard behavior therapy weight management program or a combined cognitive-behavior therapy program focused on both depression and weight management. * Complete follow up assessments of weight, depressive symptoms, and functional status in all three treatment groups for 12 months following enrollment Screening and follow-up data will be used to address the following questions: * Association between depression and obesity among middle-aged women * Specific effects of depression and obesity on functional status, disability, and health services utilization * Impact of depression on participation in and outcomes of a standardized weight management program * Benefit of combined treatment (focused on depression and weight management) above that of standardized behavioral therapy for obese women with significant depressive symptoms.

Key facts

Study ID

NCT00169273

Run by

Kaiser Permanente

People needed

192

Starts

2004-04-01

Expected to finish

2007-04-01

Last updated by the study team

2017-10-13

Who can join

Age: 40 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age 40 to 65
• Body Mass Index >= 30
• Clinically significant depression
• PHQ score of 10 or more
• Current or past major depressive episode
• Current symptoms include depressed mood or loss of interest
• Enrolled in Group Health Cooperative health plan

You may not qualify if…

• History of treatment for bipolar disorder or schizophrenia
• Not willing to participate in group intervention
• Medical contra-indications to graded exercise program
• Unable to walk for 10 minutes

Where it is running

• Group Health Research Institute — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.