Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia

Stopped early · Phase 4

Conditions studied: Schizophrenia

In brief

This study will examine the physical response to clozapine or chlorpromazine in people with schizophrenia that has not improved with treatment.

Key facts

Study ID

NCT00169039

Run by

Harvard Medical School (HMS and HSDM)

People needed

66

Starts

1994-12-01

Expected to finish

2002-02-01

Last updated by the study team

2015-04-07

Who can join

Age: 19 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 19-60 years of age
• Diagnosis of schizophrenia
• BPRS score > 50
• Clinical Global Impressions rating > 4
• One of the following: BPRS items rated greater than or equal to 4, conceptual disorganization, suspiciousness, hallucinations, unusual thought content.
• At least 2 six-week trials of different neuroleptics given at a dosage equivalent to at least 600 mg per day of chlorpromazine OR at least 1 eight-week trial of a neuroleptic given at a dosage equivalent to at least 800 mg per day of chlorpromazine.
• The patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent.

You may not qualify if…

• History of substance dependence within the past 2 months
• Major medical problems precluding the use of clozapine
• Pregnancy or lactation
• A serious suicide/homicide risk

Where it is running

• Commonwealth Research Center — Jamaica Plain, Massachusetts, United States

Full record on ClinicalTrials.gov

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