Alcoholism and Schizophrenia: Effects of Clozapine
Stopped early · Phase 4
Conditions studied: Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder, Substance Abuse, Alcohol Abuse
In brief
The purpose of this study is to examine the short - term effects of clozapine on alcohol use in persons with schizophrenia and an alcohol use disorder. The hypothesis is that clozapine will have greater efficacy in reducing alcohol use than other antipsychotic medications.
Key facts
- Study ID
- NCT00169026
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 64
- Starts
- 1999-05-01
- Expected to finish
- 2004-01-01
- Last updated by the study team
- 2018-03-14
Who can join
Age: 19 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of schizophrenia or schizoaffective disorder
- Current diagnosis of an alcohol use disorder with active use in the last 30 days.
- The participant (or the participant's authorized legal representative) understands the nature of the study and has he/she signed an informed consent.
- Ages 19-65.
- Taking olanzapine, risperidone, quetiapine or a typical antipsychotic agent for at least 8 weeks prior to study randomization
- If taking depot medication, at least 3 injection cycles since the last injection prior to study randomization.
You may not qualify if…
- Contraindication to clozapine
- Women who are currently pregnant or who desire to become pregnant during the course of the study.
- Current and past treatment with clozapine
- Current treatment with agents proposed to curtail substance use (e.g., disulfiram, naltrexone, acamprosate, buspirone) and agents contraindicated for use with clozapine (e.g., inderal, tegretol, lithium).
- Meets DSM-IV criteria for current dependence of substances other than alcohol.
Where it is running
- Commonwealth Research Center — Jamaica Plain, Massachusetts, United States
Full record on ClinicalTrials.gov
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