Effects of Venlafaxine on Chronic Neuropathic Pain Following Spinal Cord Injury
Completed · Not applicable
Conditions studied: Neuropathic Pain, Pain, Spinal Cord Injuries
In brief
The purpose of this study is to evaluate the pain-relieving effects of venlafaxine hydrochloride (Effexor) in chronic neuropathic (burning, shock-like, electric) pain after spinal cord injury (SCI). Although a number of medications have been used to treat SCI pain, no drug has been consistently helpful, and, therefore, many people with SCI continue to have difficult chronic pain. Venlafaxine is a new anti-depressant drug that has not been tested for use in SCI neuropathic pain, but has been helpful for other types of neuropathic pain.
Key facts
- Study ID
- NCT00167856
- Run by
- US Department of Veterans Affairs
- People needed
- 16
- Starts
- 2005-06-01
- Expected to finish
- 2008-08-01
- Last updated by the study team
- 2014-03-27
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- participant must be able to swallow pills
- fluent in English
- incomplete or complete spinal cord injury
- presence of at least moderately severe neuropathic pain at or below the level of injury
- spinal cord injury at least 2 year prior to entering the study
- pain for at least 6 months prior to entering the study
- spinal cord injury level above L1
- participants on anticonvulsants are considered
- approval of primary physician
You may not qualify if…
- pregnant women, or those contemplating pregnancy
- prior history of use of Venlafaxine hydrochloride (Effexor)
- current use of MAOI medications
- persons who have a recent (past year) history of alcohol or drug abuse
- persons with a history of renal disease, heart disease or uncontrolled hypertension, liver disease or hepatic cirrhosis, active major medical or psychiatric illness
- persons with a significant post-traumatic encephalopathy from head trauma sustained at SCI
- persons with tardive dyskinesia or narrow angle glaucoma
Where it is running
- VA Medical Center, Miami — Miami, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.