Campath-1H Induction to Allow Steroid Free Immunosuppression in Pediatric Renal Transplantation

Stopped early · Phase 1/Phase 2

Conditions studied: Disorder Related to Renal Transplantation

In brief

The purpose of this study is to determine whether Campath-1H induction and the associated lymphocyte depletion will permit long-term rejection-free renal allograft survival in the absence of ongoing corticosteroid administration.

Key facts

Study ID

NCT00167661

Run by

University of Wisconsin, Madison

People needed

33

Starts

2004-06-01

Expected to finish

2012-05-01

Last updated by the study team

2020-09-21

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be a single-organ recipient (kidney only)
• Participants who are receiving their first living donor or deceased donor transplant

You may not qualify if…

• Participants who are recipients of HLA-identical living-donor renal transplants
• Participants with a PRA value > 10% within 30 days prior to the transplant
• Participants who have received a multi-organ transplant
• Participants who are who are positive for hepatitis C, hepatitis B surface antigen or HIV
• Participants who have received an investigational drug within 6 weeks of study entry
• Participants who have a previous history of, or who currently have, malignancies and/or lymphoma
• Participants who have received corticosteroids within three months of transplantation
• Participants who are 3rd transplant recipients
• Female participants who are pregnant or lactating. Fertile female participants who are sexually active must agree to use an acceptable method of birth control during the study

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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