Cytokines Polymorphisms and Acetaminophen Toxicity

Completed

Conditions studied: Drug Toxicity

In brief

Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity following overdose.

Key facts

Study ID

NCT00166608

Run by

Arkansas Children's Hospital Research Institute

People needed

111

Starts

2002-12-01

Expected to finish

2007-09-01

Last updated by the study team

2012-04-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females of any age admitted to a participating site for acetaminophen overdose (acute or chronic).

You may not qualify if…

• Patients who are unable to tolerate study procedures.

Where it is running

• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• Kosair Children's Hospital — Louisville, Kentucky, United States
• Children's Hospital of Michigan — Detroit, Michigan, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• University of North Carolina--Chapel Hill — Chapel Hill, North Carolina, United States
• Rainbow Babies & Children's Hospital — Cleveland, Ohio, United States
• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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