Depression, Epinephrine, and Platelet Function
Completed · Phase 4
Conditions studied: Major Depressive Disorder
In brief
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses. What is not known is whether adult survivors of childhood adversity experience heightened negative emotions and increased physical responses due to altered norepinephrine or serotonin systems in their brains and bodies. The investigators expect to see that survivors of childhood adversity experience heightened negative emotions and increased physical responses to stress.
Key facts
- Study ID
- NCT00166114
- Run by
- Emory University
- People needed
- 40
- Starts
- 2002-02-01
- Expected to finish
- 2009-01-01
- Last updated by the study team
- 2015-07-23
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Individuals who are suicidal, psychotic, or with bipolar depression
- alcohol or substance abuse or
- regularly use medications which alter mood or blood vessel function (zolpidem or zalpelon, aspirin, nonsteroidal antiinflammatory drugs, sympatholytics, theophylline, central acting agonists, beta-blockers, coumadin, nitrates, triazolobenzodiazapines, or use steroids (testosterone-patch or pill form), use tryptophan or monoamine oxidase inhibitors (MAOIs),
- have narrow-angle glaucoma, liver disease,
- severe allergies (especially to antidepressants similar to escitalopram or desipramine)
- seizures, or a serious medical disorder (e.g. hypothyroidism) that is unstable or is untreated.
- Depressed patients with a prior history of severe adverse events associated with SSRIs or TCAs will not be accepted into the study.
Where it is running
- Emory University School of Medicine — Atlanta, Georgia, United States
Full record on ClinicalTrials.gov
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