Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy

Completed

Conditions studied: Congenital Heart Disease

In brief

There are many kids born with congenital heart disease. Some of these defects may lead to the formation of a single ventricle (the heart having only one pumping chamber). These children normally undergo a series of corrective surgeries to help overcome the problems of having just one ventricle. However there are some differences in how well the patients respond to the surgeries. In the adult population, studies have shown that there may be a genetic link that may be responsible for the differences in how patients respond. The investigators would like to study the pediatric population by looking for certain genetic markers in the patients' blood. They will also collect basic health information on each patient.

Key facts

Study ID

NCT00165984

Run by

Emory University

People needed

224

Starts

2004-01-01

Expected to finish

2010-08-01

Last updated by the study team

2012-05-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children who currently have functional single ventricle anatomy or have had heart transplantation for single ventricle anatomy who receive their cardiac care at Children's Healthcare of Atlanta, Egleston Hospital.
• Family agrees to participate in the study following informed consent

You may not qualify if…

• Conversion to two ventricle physiology, excluding transplantation.

Where it is running

• Children's Healthcare of Atlanta at Egleston — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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